Benzodiazepines. X. Oxidation of Tetrahydro-1, 4-benzo-diazepine Derivatives

An efficient one-pot synthesis of dimethyl 1-(Aryl)-5-cyano-4-(cyclohexylamino)-1,2,5,6-tetrahydro-6-oxopyridine-2,3-dicarboxylate derivatives

Abstract: The reactive 1:1 intermediate produced in the reaction between cyclohexyl isocyanide and electron- deficient acetylenic esters or dimethyl acetylene dicarboxylate was trapped by 2-cyano-N-(Aryl) acetamides to provides highly functionalized oxopyridine (potential synthetic and pharmaceutical interest )  in  acetonitrile under mild reaction conditions at ambient temperature after 24 h ...

3′-(3-Hy­droxy­phen­yl)-4-methyl­spiro­[benzo[e][1,4]diazepine-3,2′-oxirane]-2,5(1H,4H)-dione

In the title compound, C(17)H(14)N(2)O(4), the seven-membered ring adopts a boat conformation, and the two benzene rings make a dihedral angle of 45.22 (5)°. The crystal packing is stabilized by inter-molecular N-H⋯O and O-H⋯O hydrogen bonds.

Rings of functions with integer derivatives at x=1

On the oxidation of D-1, 3-thiazane-4-carboxylic acid (D-tetrahydro-1,3-thiazine-4-carboxylic acid).

Oxidation of 4-substituted TEMPO derivatives reveals modifications at the 1- and 4-positions.

Potenital pathways for the deactivation of hindered amine light stabilisers (HALS) have been investigated by observing reactions of model compounds--based on 4-substituted derivatives of 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO)--with hydroxyl radicals. In these reactions, dilute aqueous suspensions of photocatalytic nanoparticulate titanium dioxide were irradiated with UV light in the prese...